Episode 51: The Neuroscience of a Life Worth Living with Ken Mogi

Written By Kathryn Sandoe

What if the secret to a meaningful life isn’t found in success, but in the simple, joyful things that light you up? 

On this this episode, Dr. Katie sits down with neuroscientist, bestselling author, and broadcaster Ken Mogi to explore the fascinating connection between the brain and ikigai—the Japanese concept of “a life worth living.” 

Ken shows us how purpose literally rewires the brain—and why ikigai might be the missing piece to living with both success and serenity. He explains how living with ikigai doesn’t just feel good—it’s wired into our brain’s architecture. He breaks down how purpose activates the prefrontal cortex, why joy and childlike play are essential for a healthy emotional base, and how Ikigai acts as a secure foundation that allows us to embrace uncertainty, creativity, and growth without burning out.

Together, Katie and Ken unpack how purpose fuels calm, why relaxation and authenticity are critical for sustainable success, and even the surprising ways AI could threaten our sense of meaning if we’re not careful.

This conversation is part science, part soul—and a full invitation to live more deeply, joyfully, and authentically.

EPISODE RESOURCES:

Kathryn Sandoe https://www.katiesandoe.com
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Episode 50: Strong on the Outside, Starving on the Inside - A Powerful Conversation with Pastor Ray Taylor